Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts
نویسندگان
چکیده
منابع مشابه
The role of RANK/RANKL/OPG signalling pathways in osteoclastogenesis in odontogenic keratocysts, radicular cysts, and ameloblastomas.
The aim of this study was to evaluate the immunohistochemical expression of molecules involved in osteoclastogenesis, including the receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in odontogenic keratocysts (OKCs), which has been named as a keratocystic odontogenic tumour by the WHO, and compare their expression with radicular cysts and amelobl...
متن کاملDentigerous Cysts and Ameloblastomas; Expression of Mcm2 in Dentigerous Cysts and Ameloblastomas an Immunohistochemical Study
.. Objectives: The aim of study was to observe the expression of MCM2 in dentigerous cyst and ameloblastoma. Introduction: Minichromosome maintenance protein (MCM2) may be a structurally and functionally complicated replication moiety that synergizes with different molecular factors therefore regulate DNA synthesis. MCM proteins play a job in maintaining genomic integrity and stop re-replicatio...
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The aim of this study was to evaluate osteoclastogenesis signaling in midpalatal suture after rapid maxillary expansion (RME) in rats. Thirty male Wistar rats were randomly assigned to two groups with 15 animals each: control (C) and RME group. RME was performed by inserting a 1.5-mm-thick circular metal ring between the maxillary incisors. The animals were euthanized at 3, 7 and 10 days after ...
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Elucidation of the receptor activator of nuclear factor kappa B (RANK), its ligand (RANKL) and osteoprotegerin (OPG) as the final effectors of bone resorption has transformed our understanding of metabolic bone diseases and revealed novel therapeutic targets. Activation of the RANK-RANKL signaling pathway is directly responsible for dramatic focal erosions that are observed in inflammatory arth...
متن کامل[The role of RANK/RANKL and OPG in multiple myeloma].
Multiple myeloma (MM) almost exclusively develops in the bone marrow and generates devastating bone destruction by osteoclasts (OCs) recruited around myeloma cells. The severity of bone disease correlates with tumor burden. The interaction between RANK, expressed on the surface of OCs, and RANKL, a key molecule in the regulation of osteoclastogenesis expressed on bone marrow stromal cells, play...
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ژورنال
عنوان ژورنال: Archives of Oral Biology
سال: 2011
ISSN: 0003-9969
DOI: 10.1016/j.archoralbio.2011.05.009